An Experimental Toolbox for Structure‐Based Hit Discovery for P. aeruginosa FabF, a Promising Target for Antibiotics

FabF (3‐oxoacyl‐[acyl‐carrier‐protein] synthase 2), which catalyses the rate limiting condensation reaction in the fatty acid synthesis II pathway, is an attractive target for new antibiotics. Here, we focus on FabF from P. aeruginosa (PaFabF) as antibiotics against this pathogen are urgently needed...

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Detalles Bibliográficos
Autores principales: Espeland, Ludvik Olai, Georgiou, Charis, Klein, Raphael, Bhukya, Hemalatha, Haug, Bengt Erik, Underhaug, Jarl, Mainkar, Prathama S., Brenk, Ruth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8518799/
https://www.ncbi.nlm.nih.gov/pubmed/34189850
http://dx.doi.org/10.1002/cmdc.202100302

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8518799/
https://www.ncbi.nlm.nih.gov/pubmed/34189850
http://dx.doi.org/10.1002/cmdc.202100302

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