Cargando…

An Experimental Toolbox for Structure‐Based Hit Discovery for P. aeruginosa FabF, a Promising Target for Antibiotics

FabF (3‐oxoacyl‐[acyl‐carrier‐protein] synthase 2), which catalyses the rate limiting condensation reaction in the fatty acid synthesis II pathway, is an attractive target for new antibiotics. Here, we focus on FabF from P. aeruginosa (PaFabF) as antibiotics against this pathogen are urgently needed...

Descripción completa

Detalles Bibliográficos
Autores principales:	Espeland, Ludvik Olai, Georgiou, Charis, Klein, Raphael, Bhukya, Hemalatha, Haug, Bengt Erik, Underhaug, Jarl, Mainkar, Prathama S., Brenk, Ruth
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Full Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8518799/ https://www.ncbi.nlm.nih.gov/pubmed/34189850 http://dx.doi.org/10.1002/cmdc.202100302

Ejemplares similares

A Review on Platensimycin: A Selective FabF Inhibitor
por: Das, Manik, et al.
Publicado: (2016)

Functions of the Clostridium acetobutylicium FabF and FabZ proteins in unsaturated fatty acid biosynthesis
por: Zhu, Lei, et al.
Publicado: (2009)

Structural Characterisation of the Beta-Ketoacyl-Acyl Carrier Protein Synthases, FabF and FabH, of Yersinia pestis
por: Nanson, Jeffrey D., et al.
Publicado: (2015)

Crystal structure of Pseudomonas aeruginosa FabB C161A, a template for structure-based design for new antibiotics
por: Yadrykhins'ky, Vladyslav, et al.
Publicado: (2022)

Structural characterisation of the fatty acid biosynthesis enzyme FabF from the pathogen Listeria monocytogenes
por: Soares da Costa, Tatiana P., et al.
Publicado: (2017)

Structures of Pseudomonas aeruginosa β-ketoacyl-(acyl-carrier-protein) synthase II (FabF) and a C164Q mutant provide templates for antibacterial drug discovery and identify a buried potassium ion and a ligand-binding site that is an artefact of the crystal form
por: Baum, Bernhard, et al.
Publicado: (2015)

The Deleterious Effects of Shiga Toxin Type 2 Are Neutralized In Vitro by FabF8:Stx2 Recombinant Monoclonal Antibody
por: Luz, Daniela, et al.
Publicado: (2021)

Improved chemical and isotopic labeling of biomembranes in Bacillus subtilis by leveraging CRISPRi inhibition of beta-ketoacyl-ACP synthase (fabF)
por: Nickels, Jonathan D., et al.
Publicado: (2022)

To Hit or Not to Hit, That Is the Question – Genome-wide Structure-Based Druggability Predictions for Pseudomonas aeruginosa Proteins
por: Sarkar, Aurijit, et al.
Publicado: (2015)

Eye: The Hard-hit Victim of COVID-19 Pandemic
por: Gaur, Aman, et al.
Publicado: (2022)

Synthesis of Asthma Drug Zafirlukast (Accolate) Using Intramolecular Oxidative Coupling via sp(3) C–H Bond Activation
por: Paladugu, Srinu, et al.
Publicado: (2018)

CONQUER: an interactive toolbox to understand functional consequences of GWAS hits
por: Bouland, Gerard A, et al.
Publicado: (2020)

Phenylalanine Hydroxylase Misfolding and Pharmacological Chaperones
por: Underhaug, Jarl, et al.
Publicado: (2012)

Characterization of Molecular Mechanisms Controlling fabAB Transcription in Pseudomonas aeruginosa
por: Schweizer, Herbert P., et al.
Publicado: (2012)

Diastereoselective synthesis of CF(3)-dihydrobenzofurans by [4+1] annulation of in situ-generated CF(3)-o-quinone methides and sulfur ylides
por: Jha, Babli K., et al.
Publicado: (2020)

Emulsion and Surface-Active Properties of Fish Solubles Based on Direct Extraction and after Hydrolysis of Atlantic Cod and Atlantic Salmon Backbones
por: Steinsholm, Silje, et al.
Publicado: (2020)

A Workup Protocol Combined with Direct Application of Quantitative Nuclear Magnetic Resonance Spectroscopy of Aqueous Samples from Large-Scale Steam Explosion of Biomass
por: Løhre, Camilla, et al.
Publicado: (2021)

Single chain Fab (scFab) fragment
por: Hust, Michael, et al.
Publicado: (2007)

A Substrate Mimic Allows High-Throughput Assay of the FabA Protein and Consequently the Identification of a Novel Inhibitor of Pseudomonas aeruginosa FabA
por: Moynié, Lucile, et al.
Publicado: (2016)

Continuous flow process for preparing budesonide
por: Phull, Manjinder Singh, et al.
Publicado: (2022)

Fast Mapping of Global Protein Folding States by Multivariate NMR: A GPS for Proteins
por: Malmendal, Anders, et al.
Publicado: (2010)

Quantification of Polyphenols in Seaweeds: A Case Study of Ulva intestinalis
por: Wekre, Marie Emilie, et al.
Publicado: (2019)

Production of single chain Fab (scFab) fragments in Bacillus megaterium
por: Jordan, Eva, et al.
Publicado: (2007)

Functional Characterization of Triclosan-Resistant Enoyl-acyl-carrier Protein Reductase (FabV) in Pseudomonas aeruginosa
por: Huang, Yong-Heng, et al.
Publicado: (2016)

In vitro and in vivo studies reveal α-Mangostin, a xanthonoid from Garcinia mangostana, as a promising natural antiviral compound against chikungunya virus
por: Patil, Poonam, et al.
Publicado: (2021)

Locating Sweet Spots for Screening Hits and Evaluating Pan-Assay Interference Filters from the Performance Analysis of Two Lead-like Libraries
por: Mok, N. Yi, et al.
Publicado: (2013)

DutaFabs are engineered therapeutic Fab fragments that can bind two targets simultaneously
por: Beckmann, Roland, et al.
Publicado: (2021)

Total Synthesis of Desmethyl Jahanyne and Its Lipo-Tetrapeptide Conjugates Derived from Parent Skeleton as BCL-2-Mediated Apoptosis-Inducing Agents
por: Kallepu, Shivakrishna, et al.
Publicado: (2018)

Total synthesis of antiviral drug, nirmatrelvir (PF-07321332)
por: Shekhar, Chandra, et al.
Publicado: (2022)

Fab : the coming revolution on your desktop--from personal computers to personal fabrication
por: Gershenfeld, Neil A.
Publicado: (2005)

FabR regulates Salmonella biofilm formation via its direct target FabB
por: Hermans, Kim, et al.
Publicado: (2016)

Identification of New Molecular Entities (NMEs) as Potential Leads against Tuberculosis from Open Source Compound Repository
por: Kotapalli, Sudha Sravanti, et al.
Publicado: (2015)

In silico identification and experimental validation of hits active against KPC-2 β-lactamase
por: Klein, Raphael, et al.
Publicado: (2018)

In Vitro Antiviral Activity of α-Mangostin against Dengue Virus Serotype-2 (DENV-2)
por: Panda, Kingshuk, et al.
Publicado: (2021)

Self-fab house : 2nd Advanced Architecture Contest /
Publicado: (2009)

Fab-arm exchange is a misnomer
por: Pandey, Janardan P.
Publicado: (2012)

Meditope–Fab interaction: threading the hole
por: Bzymek, Krzysztof P., et al.
Publicado: (2017)

Ranking routes in semiconductor wafer fabs
por: Gupta, Shreya, et al.
Publicado: (2023)

Analysis of the Plasmid-Based ts-Mutant ΔfabA/pTS-fabA Reveals Its Lethality under Aerobic Growth Conditions That Is Suppressed by Mild Overexpression of desA at a Restrictive Temperature in Pseudomonas aeruginosa
por: Tian, Liyan, et al.
Publicado: (2023)

Mutations upstream of fabI in triclosan resistant Staphylococcus aureus strains are associated with elevated fabI gene expression
por: Grandgirard, Denis, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_t5dnqmc9ttu9skt1tsroeas72f