A Computer‐Driven Scaffold‐Hopping Approach Generating New PTP1B Inhibitors from the Pyrrolo[1,2‐a]quinoxaline Core

Protein tyrosine phosphatase 1B (PTP1B) is a very promising target for the treatment of metabolic disorders such as type II diabetes mellitus. Although it was validated as a promising target for this disease more than 30 years ago, as yet there is no drug in advanced clinical trials, and its biochem...

Descripción completa

Detalles Bibliográficos
Autores principales: García‐Marín, Javier, Griera, Mercedes, Alajarín, Ramón, Rodríguez‐Puyol, Manuel, Rodríguez‐Puyol, Diego, Vaquero, Juan J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8518816/
https://www.ncbi.nlm.nih.gov/pubmed/34137509
http://dx.doi.org/10.1002/cmdc.202100338

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8518816/
https://www.ncbi.nlm.nih.gov/pubmed/34137509
http://dx.doi.org/10.1002/cmdc.202100338

Ejemplares similares