Engineered RebH Halogenase Variants Demonstrating a Specificity Switch from Tryptophan towards Novel Indole Compounds

Activating industrially important aromatic hydrocarbons by installing halogen atoms is extremely important in organic synthesis and often improves the pharmacological properties of drug molecules. To this end, tryptophan halogenase enzymes are potentially valuable tools for regioselective halogenati...

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Detalles Bibliográficos
Autores principales: Sana, Barindra, Ho, Timothy, Kannan, Srinivasaraghavan, Ke, Ding, Li, Eunice H. Y., Seayad, Jayasree, Verma, Chandra S., Duong, Hung A., Ghadessy, Farid J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8518859/
https://www.ncbi.nlm.nih.gov/pubmed/34240527
http://dx.doi.org/10.1002/cbic.202100210

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8518859/
https://www.ncbi.nlm.nih.gov/pubmed/34240527
http://dx.doi.org/10.1002/cbic.202100210

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