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Engineered RebH Halogenase Variants Demonstrating a Specificity Switch from Tryptophan towards Novel Indole Compounds
Activating industrially important aromatic hydrocarbons by installing halogen atoms is extremely important in organic synthesis and often improves the pharmacological properties of drug molecules. To this end, tryptophan halogenase enzymes are potentially valuable tools for regioselective halogenati...
Autores principales: | Sana, Barindra, Ho, Timothy, Kannan, Srinivasaraghavan, Ke, Ding, Li, Eunice H. Y., Seayad, Jayasree, Verma, Chandra S., Duong, Hung A., Ghadessy, Farid J. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8518859/ https://www.ncbi.nlm.nih.gov/pubmed/34240527 http://dx.doi.org/10.1002/cbic.202100210 |
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