Cargando…

Oxidized low‐density lipoprotein activates extracellular signal‐regulated kinase signaling to downregulate sortilin expression in liver sinusoidal endothelial cells

BACKGROUND AND AIM: Both type 2 diabetes mellitus and non‐alcoholic fatty liver disease are closely associated with elevated levels of low‐density lipoprotein cholesterol and its oxidized form (ox‐LDL). This study aimed to investigate the regulation of sortilin in liver tissue and its potential impl...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Qi, Lin, Wenyan, Tian, Limin, Di, Baoshan, Yu, Jing, Niu, Xiang'e, Liu, Jing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Experimental Hepatology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8518938/ https://www.ncbi.nlm.nih.gov/pubmed/33694195 http://dx.doi.org/10.1111/jgh.15486

Ejemplares similares

Sortilin as a Regulator of Lipoprotein Metabolism
por: Strong, Alanna, et al.
Publicado: (2012)

LTβR signalling preferentially accelerates oncogenic AKT-initiated liver tumours
por: Scarzello, Anthony J, et al.
Publicado: (2016)

NFATc1 signaling drives chronic ER stress responses to promote NAFLD progression
por: Latif, Muhammad Umair, et al.
Publicado: (2022)

Signalling via the osteopontin and high mobility group box-1 axis drives the fibrogenic response to liver injury
por: Arriazu, Elena, et al.
Publicado: (2017)

Association of low-density lipoprotein cholesterol within the normal range and NAFLD in the non-obese Chinese population: a cross-sectional and longitudinal study
por: Sun, Dan-Qin, et al.
Publicado: (2016)

miR-135a-5p-mediated downregulation of protein tyrosine phosphatase receptor delta is a candidate driver of HCV-associated hepatocarcinogenesis
por: Van Renne, Nicolaas, et al.
Publicado: (2018)

The microtubule-associated protein PRC1 promotes early recurrence of hepatocellular carcinoma in association with the Wnt/β-catenin signalling pathway
por: Chen, Jianxiang, et al.
Publicado: (2016)

Engineered anti-PDL1 with IFNα targets both immunoinhibitory and activating signals in the liver to break HBV immune tolerance
por: Meng, Chao-Yang, et al.
Publicado: (2023)

Colesevelam attenuates cholestatic liver and bile duct injury in Mdr2(−/−) mice by modulating composition, signalling and excretion of faecal bile acids
por: Fuchs, Claudia Daniela, et al.
Publicado: (2018)

Glial cell line-derived neurotrophic factor (GDNF) mediates hepatic stellate cell activation via ALK5/Smad signalling
por: Tao, Le, et al.
Publicado: (2019)

Extracellular lipid-free apolipoprotein E inhibits HCV replication and induces ABCG1-dependent cholesterol efflux
por: Crouchet, Emilie, et al.
Publicado: (2017)

S100A10 promotes HCC development and progression via transfer in extracellular vesicles and regulating their protein cargos
por: Wang, Xia, et al.
Publicado: (2023)

Editorial: Sortilin and Sortilin Partners in Physiology and Pathologies
por: Mazella, Jean, et al.
Publicado: (2019)

Association between lymphocyte-to-monocyte ratio (LMR) and the mortality of HBV-related liver cirrhosis: a retrospective cohort study
por: Zhang, Jie, et al.
Publicado: (2015)

Dimerization of sortilin regulates its trafficking to extracellular vesicles
por: Itoh, Shinsuke, et al.
Publicado: (2018)

Regulatory NK cells mediated between immunosuppressive monocytes and dysfunctional T cells in chronic HBV infection
por: Li, Haijun, et al.
Publicado: (2018)

TLR signals posttranscriptionally regulate the cytokine trafficking mediator sortilin
por: Yabe-Wada, Toshiki, et al.
Publicado: (2016)

A disrupted RNA editing balance mediated by ADARs (Adenosine DeAminases that act on RNA) in human hepatocellular carcinoma
por: Chan, Tim Hon Man, et al.
Publicado: (2014)

Alcohol inhibits T-cell glucose metabolism and hepatitis in ALDH2-deficient mice and humans: roles of acetaldehyde and glucocorticoids
por: Gao, Yanhang, et al.
Publicado: (2019)

HBV infection-induced liver cirrhosis development in dual-humanised mice with human bone mesenchymal stem cell transplantation
por: Yuan, Lunzhi, et al.
Publicado: (2019)

Single-cell RNA sequencing reveals intrahepatic and peripheral immune characteristics related to disease phases in HBV-infected patients
por: Zhang, Chao, et al.
Publicado: (2023)

PAK Kinases Target Sortilin and Modulate Its Sorting
por: Pallesen, Lone Tjener, et al.
Publicado: (2020)

Baseline quantitative hepatitis B core antibody titre alone strongly predicts HBeAg seroconversion across chronic hepatitis B patients treated with peginterferon or nucleos(t)ide analogues
por: Fan, Rong, et al.
Publicado: (2016)

Sortilin and atherosclerosis
por: Mortensen, Martin B., et al.
Publicado: (2015)

PBMC transcriptomics identifies immune-metabolism disorder during the development of HBV-ACLF
por: Li, Jiang, et al.
Publicado: (2022)

Distribution and clinical correlates of viral and host genotypes in Chinese patients with chronic hepatitis C virus infection
por: Rao, Huiying, et al.
Publicado: (2014)

Targeting PPAR-gamma counteracts tumour adaptation to immune-checkpoint blockade in hepatocellular carcinoma
por: Xiong, Zhewen, et al.
Publicado: (2023)

A curcumin analog GL63 inhibits the malignant behaviors of hepatocellular carcinoma by inactivating the JAK2/STAT3 signaling pathway via the circular RNA zinc finger protein 83/microRNA‐324‐5p/cyclin‐dependent kinase 16 axis
por: Zhao, Ji‐an, et al.
Publicado: (2021)

Dissecting the role of sortilin receptor signaling in neurodegeneration induced by NGF deprivation
por: Capsoni, Simona, et al.
Publicado: (2013)

Sortilin limits EGFR signaling by promoting its internalization in lung cancer
por: Al-Akhrass, Hussein, et al.
Publicado: (2017)

Sortilin gates neurotensin and BDNF signaling to control peripheral neuropathic pain
por: Richner, Mette, et al.
Publicado: (2019)

A practical nomogram based on systemic inflammatory markers for predicting portal vein thrombosis in patients with liver cirrhosis
por: Xing, Yueyi, et al.
Publicado: (2022)

Fast-food-based hyper-alimentation can induce rapid and profound elevation of serum alanine aminotransferase in healthy subjects
por: Kechagias, S, et al.
Publicado: (2008)

Costs and cost-effectiveness of different follow-up schedules for detection of occupational hepatitis C virus infection
por: Deuffic-Burban, S, et al.
Publicado: (2008)

Risk factors for acute hepatitis B and its progression to chronic hepatitis in Shanghai, China
por: Zhang, H W, et al.
Publicado: (2008)

Molecular footprints reveal the impact of the protective HLA-A*03 allele in hepatitis C virus infection
por: Fitzmaurice, Karen, et al.
Publicado: (2011)

Resistance exercise reduces liver fat and its mediators in non-alcoholic fatty liver disease independent of weight loss
por: Hallsworth, Kate, et al.
Publicado: (2011)

Impaired plasmacytoid dendritic cell maturation and differential chemotaxis in chronic hepatitis C virus: associations with antiviral treatment outcomes
por: Mengshol, J A, et al.
Publicado: (2009)

Chemokine-driven lymphocyte infiltration: an early intratumoural event determining long-term survival in resectable hepatocellular carcinoma
por: Chew, Valerie, et al.
Publicado: (2011)

Predicting spontaneous clearance of acute hepatitis C virus in a large cohort of HIV-1-infected men
por: Thomson, Emma C, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_ec4ib6fibecmetidt7noh8ue3m