Structure‐Activity Relationship and Mode‐Of‐Action Studies Highlight 1‐(4‐Biphenylylmethyl)‐1H‐imidazole‐Derived Small Molecules as Potent CYP121 Inhibitors

CYP121 of Mycobacterium tuberculosis (Mtb) is an essential target for the development of novel potent drugs against tuberculosis (TB). Besides known antifungal azoles, further compounds of the azole class were recently identified as CYP121 inhibitors with antimycobacterial activity. Herein, we repor...

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Detalles Bibliográficos
Autores principales: Walter, Isabell, Adam, Sebastian, Gentilini, Maria Virginia, Kany, Andreas M., Brengel, Christian, Thomann, Andreas, Sparwasser, Tim, Köhnke, Jesko, Hartmann, Rolf W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8519103/
https://www.ncbi.nlm.nih.gov/pubmed/34010508
http://dx.doi.org/10.1002/cmdc.202100283

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8519103/
https://www.ncbi.nlm.nih.gov/pubmed/34010508
http://dx.doi.org/10.1002/cmdc.202100283

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