Mislocalization of Nucleocytoplasmic Transport Proteins in Human Huntington’s Disease PSC-Derived Striatal Neurons

Huntington’s disease (HD) is an inherited neurodegenerative disorder caused by a CAG repeat expansion in the huntingtin gene (HTT). Disease progression is characterized by the loss of vulnerable neuronal populations within the striatum. A consistent phenotype across HD models is disruption of nucleo...

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Detalles Bibliográficos
Autores principales: Lange, Jenny, Wood-Kaczmar, Alison, Ali, Aneesa, Farag, Sahar, Ghosh, Rhia, Parker, Jennifer, Casey, Caroline, Uno, Yumiko, Kunugi, Akiyoshi, Ferretti, Patrizia, Andre, Ralph, Tabrizi, Sarah J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8519404/
https://www.ncbi.nlm.nih.gov/pubmed/34658796
http://dx.doi.org/10.3389/fncel.2021.742763

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8519404/
https://www.ncbi.nlm.nih.gov/pubmed/34658796
http://dx.doi.org/10.3389/fncel.2021.742763

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