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DeepCellState: An autoencoder-based framework for predicting cell type specific transcriptional states induced by drug treatment

Drug treatment induces cell type specific transcriptional programs, and as the number of combinations of drugs and cell types grows, the cost for exhaustive screens measuring the transcriptional drug response becomes intractable. We developed DeepCellState, a deep learning autoencoder-based framewor...

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Detalles Bibliográficos
Autores principales: Umarov, Ramzan, Li, Yu, Arner, Erik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8519465/
https://www.ncbi.nlm.nih.gov/pubmed/34610009
http://dx.doi.org/10.1371/journal.pcbi.1009465