Designed, highly expressing, thermostable dengue virus 2 envelope protein dimers elicit quaternary epitope antibodies

Dengue virus (DENV) is a worldwide health burden, and a safe vaccine is needed. Neutralizing antibodies bind to quaternary epitopes on DENV envelope (E) protein homodimers. However, recombinantly expressed soluble E proteins are monomers under vaccination conditions and do not present these quaterna...

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Detalles Bibliográficos
Autores principales: Kudlacek, Stephan T., Metz, Stefan, Thiono, Devina, Payne, Alexander M., Phan, Thanh T. N., Tian, Shaomin, Forsberg, Lawrence J., Maguire, Jack, Seim, Ian, Zhang, Shu, Tripathy, Ashutosh, Harrison, Joseph, Nicely, Nathan I., Soman, Sandrine, McCracken, Michael K., Gromowski, Gregory D., Jarman, Richard G., Premkumar, Lakshmanane, de Silva, Aravinda M., Kuhlman, Brian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8519570/
https://www.ncbi.nlm.nih.gov/pubmed/34652943
http://dx.doi.org/10.1126/sciadv.abg4084

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8519570/
https://www.ncbi.nlm.nih.gov/pubmed/34652943
http://dx.doi.org/10.1126/sciadv.abg4084

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