Progressive alterations in amino acid and lipid metabolism correlate with peripheral neuropathy in Polg(D257A) mice

Mitochondria are central to metabolic homeostasis, and progressive mitochondrial defects have diverse metabolic consequences that could drive distinct pathophysiological states. Here, we comprehensively characterized metabolic alterations in Polg(D257A) mice. Plasma alanine increased markedly with t...

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Detalles Bibliográficos
Autores principales: Lim, Esther W., Handzlik, Michal K., Trefts, Elijah, Gengatharan, Jivani M., Pondevida, Carlos M., Shaw, Reuben J., Metallo, Christian M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8519573/
https://www.ncbi.nlm.nih.gov/pubmed/34652935
http://dx.doi.org/10.1126/sciadv.abj4077

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8519573/
https://www.ncbi.nlm.nih.gov/pubmed/34652935
http://dx.doi.org/10.1126/sciadv.abj4077

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