ULK1 promotes mitophagy via phosphorylation and stabilization of BNIP3

UNC51-like kinase-1 (ULK1) is the catalytic component of the autophagy pre-initiation complex that stimulates autophagy via phosphorylation of ATG14, BECLN1 and other autophagy proteins. ULK1 has also been shown to specifically promote mitophagy but the mechanistic basis of how has remained unclear....

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Detalles Bibliográficos
Autores principales: Poole, Logan P., Bock-Hughes, Althea, Berardi, Damian E., Macleod, Kay F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8519931/
https://www.ncbi.nlm.nih.gov/pubmed/34654847
http://dx.doi.org/10.1038/s41598-021-00170-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8519931/
https://www.ncbi.nlm.nih.gov/pubmed/34654847
http://dx.doi.org/10.1038/s41598-021-00170-4

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