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ULK1 promotes mitophagy via phosphorylation and stabilization of BNIP3
UNC51-like kinase-1 (ULK1) is the catalytic component of the autophagy pre-initiation complex that stimulates autophagy via phosphorylation of ATG14, BECLN1 and other autophagy proteins. ULK1 has also been shown to specifically promote mitophagy but the mechanistic basis of how has remained unclear....
Autores principales: | Poole, Logan P., Bock-Hughes, Althea, Berardi, Damian E., Macleod, Kay F. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8519931/ https://www.ncbi.nlm.nih.gov/pubmed/34654847 http://dx.doi.org/10.1038/s41598-021-00170-4 |
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