A C. elegans model of C9orf72-associated ALS/FTD uncovers a conserved role for eIF2D in RAN translation

A hexanucleotide repeat expansion GGGGCC in the non-coding region of C9orf72 is the most common cause of inherited amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Toxic dipeptide repeats (DPRs) are synthesized from GGGGCC via repeat-associated non-AUG (RAN) translation. Here,...

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Detalles Bibliográficos
Autores principales: Sonobe, Yoshifumi, Aburas, Jihad, Krishnan, Gopinath, Fleming, Andrew C., Ghadge, Ghanashyam, Islam, Priota, Warren, Eleanor C., Gu, Yuanzheng, Kankel, Mark W., Brown, André E. X., Kiskinis, Evangelos, Gendron, Tania F., Gao, Fen-Biao, Roos, Raymond P., Kratsios, Paschalis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8519953/
https://www.ncbi.nlm.nih.gov/pubmed/34654821
http://dx.doi.org/10.1038/s41467-021-26303-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8519953/
https://www.ncbi.nlm.nih.gov/pubmed/34654821
http://dx.doi.org/10.1038/s41467-021-26303-x

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