The loss of DHX15 impairs endothelial energy metabolism, lymphatic drainage and tumor metastasis in mice

DHX15 is a downstream substrate for Akt1, which is involved in key cellular processes affecting vascular biology. Here, we explored the vascular regulatory function of DHX15. Homozygous DHX15 gene deficiency was lethal in mouse and zebrafish embryos. DHX15(—/—) zebrafish also showed downregulation o...

Descripción completa

Detalles Bibliográficos
Autores principales: Ribera, Jordi, Portolés, Irene, Córdoba-Jover, Bernat, Rodríguez-Vita, Juan, Casals, Gregori, González-de la Presa, Bernardino, Graupera, Mariona, Solsona-Vilarrasa, Estel, Garcia-Ruiz, Carmen, Fernández-Checa, José C., Soria, Guadalupe, Tudela, Raúl, Esteve-Codina, Anna, Espadas, Guadalupe, Sabidó, Eduard, Jiménez, Wladimiro, Sessa, William C., Morales-Ruiz, Manuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8519955/
https://www.ncbi.nlm.nih.gov/pubmed/34654883
http://dx.doi.org/10.1038/s42003-021-02722-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8519955/
https://www.ncbi.nlm.nih.gov/pubmed/34654883
http://dx.doi.org/10.1038/s42003-021-02722-w

Ejemplares similares