FDA approved L-type channel blocker Nifedipine reduces cell death in hypoxic A549 cells through modulation of mitochondrial calcium and superoxide generation

As hypoxia is a major driver for the pathophysiology of COVID-19, it is crucial to characterize the hypoxic response at the cellular and molecular levels. In order to augment drug repurposing with the identification of appropriate molecular targets, investigations on therapeutics preventing hypoxic...

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Detalles Bibliográficos
Autores principales: Manohar, Kuruba, Gupta, Rishikesh Kumar, Gupta, Parth, Saha, Debasmita, Gare, Suman, Sarkar, Rahuldeb, Misra, Ashish, Giri, Lopamudra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Inc. 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8520174/
https://www.ncbi.nlm.nih.gov/pubmed/34666149
http://dx.doi.org/10.1016/j.freeradbiomed.2021.08.245

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8520174/
https://www.ncbi.nlm.nih.gov/pubmed/34666149
http://dx.doi.org/10.1016/j.freeradbiomed.2021.08.245

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