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A positive feedback loop of lncRNA-RMRP/ZNRF3 axis and Wnt/β-catenin signaling regulates the progression and temozolomide resistance in glioma

Drug resistance strikingly limits the therapeutic effect of temozolomide (TMZ) (a common drug for glioma). Long non-coding RNA (lncRNA) RMRP has been found to be implicated in glioma progression. However, the effect of RMRP on TMZ resistance along with related molecular mechanisms is poorly defined...

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Detalles Bibliográficos
Autores principales: Liu, Tie, Hu, Jie, Han, Bo, Tan, Shishan, Jia, Wenqing, Xin, Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8520527/
https://www.ncbi.nlm.nih.gov/pubmed/34657141
http://dx.doi.org/10.1038/s41419-021-04245-y