Class-II dihydroorotate dehydrogenases from three phylogenetically distant fungi support anaerobic pyrimidine biosynthesis

BACKGROUND: In most fungi, quinone-dependent Class-II dihydroorotate dehydrogenases (DHODs) are essential for pyrimidine biosynthesis. Coupling of these Class-II DHODHs to mitochondrial respiration makes their in vivo activity dependent on oxygen availability. Saccharomyces cerevisiae and closely re...

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Detalles Bibliográficos
Autores principales: Bouwknegt, Jonna, Koster, Charlotte C., Vos, Aurin M., Ortiz-Merino, Raúl A., Wassink, Mats, Luttik, Marijke A. H., van den Broek, Marcel, Hagedoorn, Peter L., Pronk, Jack T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8520639/
https://www.ncbi.nlm.nih.gov/pubmed/34656184
http://dx.doi.org/10.1186/s40694-021-00117-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8520639/
https://www.ncbi.nlm.nih.gov/pubmed/34656184
http://dx.doi.org/10.1186/s40694-021-00117-4

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