Betulinic acid decreases lipid accumulation in adipogenesis-induced human mesenchymal stem cells with upregulation of PGC-1α and UCP-1 and post-transcriptional downregulation of adiponectin and leptin secretion

BACKGROUND: Controlling cellular functions, including stem cell growth and differentiation, can be the key for the treatment of metabolic disorders, such as type II diabetes mellitus (T2DM). Previously identified as peroxisome proliferator-activated receptor gamma (PPARγ) antagonist, betulinic acid...

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Detalles Bibliográficos
Autores principales: Senamontree, Sasithon, Lakthan, Thitiporn, Charoenpanich, Pornsri, Chanchao, Chanpen, Charoenpanich, Adisri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2021
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8520689/
https://www.ncbi.nlm.nih.gov/pubmed/34721992
http://dx.doi.org/10.7717/peerj.12321

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8520689/
https://www.ncbi.nlm.nih.gov/pubmed/34721992
http://dx.doi.org/10.7717/peerj.12321

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