Increased mitochondrial calcium uptake and concomitant mitochondrial activity by presenilin loss promotes mTORC1 signaling to drive neurodegeneration

Metabolic dysfunction and protein aggregation are common characteristics that occur in age‐related neurodegenerative disease. However, the mechanisms underlying these abnormalities remain poorly understood. We have found that mutations in the gene encoding presenilin in Caenorhabditis elegans, sel‐1...

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Detalles Bibliográficos
Autores principales: Ryan, Kerry C., Ashkavand, Zahra, Sarasija, Shaarika, Laboy, Jocelyn T., Samarakoon, Rohan, Norman, Kenneth R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8520713/
https://www.ncbi.nlm.nih.gov/pubmed/34499406
http://dx.doi.org/10.1111/acel.13472

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8520713/
https://www.ncbi.nlm.nih.gov/pubmed/34499406
http://dx.doi.org/10.1111/acel.13472

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