Cargando…

Identification of a small molecule SR9009 that activates NRF2 to counteract cellular senescence

The senescence‐associated secretory phenotype (SASP) is a striking characteristic of senescence. Accumulation of SASP factors causes a pro‐inflammatory response linked to chronic disease. Suppressing senescence and SASP represents a strategy to prevent or control senescence‐associated diseases. Here...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gao, Li‐Bin, Wang, Ya‐Hong, Liu, Zhi‐Hua, Sun, Yu, Cai, Peng, Jing, Qing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Original Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8520720/ https://www.ncbi.nlm.nih.gov/pubmed/34587364 http://dx.doi.org/10.1111/acel.13483

Ejemplares similares

In Vitro Metabolic Studies of REV-ERB Agonists SR9009 and SR9011
por: Geldof, Lore, et al.
Publicado: (2016)

SR9009 Regulates Acute Lung Injury in Mice Induced by Sepsis
por: Hu, Ming, et al.
Publicado: (2022)

Rev-erbα agonist SR9009 protects against cerebral ischemic injury through mechanisms involving Nrf2 pathway
por: Sheng, Mingyue, et al.
Publicado: (2023)

REV-ERBα Agonist SR9009 Promotes a Negative Energy Balance in Goldfish
por: Saiz, Nuria, et al.
Publicado: (2022)

SR9009 improves heart function after pressure overload independent of cardiac REV-ERB
por: Li, Hui, et al.
Publicado: (2022)

SR9009 induces a REV-ERB dependent anti-small-cell lung cancer effect through inhibition of autophagy
por: Shen, Weitao, et al.
Publicado: (2020)

Chemotherapeutic Effect of SR9009, a REV-ERB Agonist, on the Human Glioblastoma T98G Cells
por: Wagner, Paula M., et al.
Publicado: (2019)

SR9009 administered for one day after myocardial ischemia-reperfusion prevents heart failure in mice by targeting the cardiac inflammasome
por: Reitz, Cristine J., et al.
Publicado: (2019)

SR9009 inhibits lethal prostate cancer subtype 1 by regulating the LXRα/FOXM1 pathway independently of REV-ERBs
por: Xu, Hang, et al.
Publicado: (2022)

ZKSCAN3 counteracts cellular senescence by stabilizing heterochromatin
por: Hu, Huifang, et al.
Publicado: (2020)

Small molecule compounds that induce cellular senescence
por: Petrova, Nadezhda V., et al.
Publicado: (2016)

The Putatively Specific Synthetic REV-ERB Agonist SR9009 Inhibits IgE- and IL-33-Mediated Mast Cell Activation Independently of the Circadian Clock
por: Ishimaru, Kayoko, et al.
Publicado: (2019)

Circadian Clock REV-ERBs Agonist SR9009 Induces Synergistic Antitumor Activity in Multiple Myeloma by Suppressing Glucose-Regulated Protein 78-Dependent Autophagy and Lipogenesis
por: Wang, Rui, et al.
Publicado: (2023)

A Small Molecule That Promotes Cellular Senescence Prevents Fibrogenesis and Tumorigenesis
por: Meang, Moon Kee, et al.
Publicado: (2022)

SIRT3 consolidates heterochromatin and counteracts senescence
por: Diao, Zhiqing, et al.
Publicado: (2021)

PPARgamma Deficiency Counteracts Thymic Senescence
por: Ernszt, David, et al.
Publicado: (2017)

Small‐molecule inhibition of aging‐associated chromosomal instability delays cellular senescence
por: Barroso‐Vilares, Monika, et al.
Publicado: (2020)

Activators of Nrf2 to Counteract Neurodegenerative Diseases
por: Amoroso, Rosa, et al.
Publicado: (2023)

Correction to ‘SIRT3 consolidates heterochromatin and counteracts senescence’
por: Diao, Zhiqing, et al.
Publicado: (2021)

Small molecule modulation of splicing factor expression is associated with rescue from cellular senescence
por: Latorre, Eva, et al.
Publicado: (2017)

FTO stabilizes MIS12 and counteracts senescence
por: Zhang, Sheng, et al.
Publicado: (2022)

The role of Nrf2 signaling in counteracting neurodegenerative diseases
por: Dinkova‐Kostova, Albena T., et al.
Publicado: (2018)

A small molecule inhibitor of PAI-1 protects against doxorubicin-induced cellular senescence
por: Ghosh, Asish K., et al.
Publicado: (2016)

Stress granules counteract senescence by sequestration of PAI‐1
por: Omer, Amr, et al.
Publicado: (2018)

SR140333 counteracts NK-1 mediated cell proliferation in human breast cancer cell line T47D
por: Huang, Wei-Qing, et al.
Publicado: (2010)

Carbofuran affects cellular autophagy and developmental senescence through the impairment of Nrf2 signalling
por: Khan, Alam, et al.
Publicado: (2021)

High-throughput small molecule screening reveals Nrf2-dependent and -independent pathways of cellular stress resistance
por: Lombard, David B., et al.
Publicado: (2020)

A Small-Molecule Probe of the Histone Methyltransferase G9a Induces Cellular Senescence in Pancreatic Adenocarcinoma
por: Yuan, Yuan, et al.
Publicado: (2012)

Fanconi anemia proteins counteract the implementation of the oncogene-induced senescence program
por: Helbling-Leclerc, Anne, et al.
Publicado: (2019)

Identification of cellular senescence-specific genes by comparative transcriptomics
por: Nagano, Taiki, et al.
Publicado: (2016)

Evaluation and identification of stem rust resistance genes Sr2, Sr24, Sr25, Sr26, Sr31 and Sr38 in wheat lines from Gansu Province in China
por: Xu, Xiao Feng, et al.
Publicado: (2017)

Identification of a novel small-molecule Keap1–Nrf2 PPI inhibitor with cytoprotective effects on LPS-induced cardiomyopathy
por: Jiang, Cheng-Shi, et al.
Publicado: (2018)

Herb-Derived Products: Natural Tools to Delay and Counteract Stem Cell Senescence
por: Abruzzo, Provvidenza M., et al.
Publicado: (2020)

Cellular senescence, senescence-associated secretory phenotype, and chronic kidney disease
por: Wang, Wen-Juan, et al.
Publicado: (2017)

Human Placental Extract Delays In Vitro Cellular Senescence through the Activation of NRF2-Mediated Antioxidant Pathway
por: Huang, Liguo, et al.
Publicado: (2022)

Targeting Mitochondria to Counteract Age-Related Cellular Dysfunction
por: Madreiter-Sokolowski, Corina T., et al.
Publicado: (2018)

Markers of cellular senescence. Telomere shortening as a marker of cellular senescence
por: Bernadotte, Alexandra, et al.
Publicado: (2016)

The Nrf2/ARE Pathway: A Promising Target to Counteract Mitochondrial Dysfunction in Parkinson's Disease
por: Tufekci, Kemal Ugur, et al.
Publicado: (2011)

Induction, regulation and roles of neural adhesion molecule L1CAM in cellular senescence
por: Mrazkova, Blanka, et al.
Publicado: (2018)

Unravelling Cellular Mechanisms of Stem Cell Senescence: An Aid from Natural Bioactive Molecules
por: Cruciani, Sara, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_p0q9t50qdom63o56nimuhb484f