Pharmacokinetic modeling of R and S‐Methadone and their metabolites to study the effects of various covariates in post‐operative children

Methadone is a synthetic opioid used as an analgesic and for the treatment of opioid abuse disorder. The analgesic dose in the pediatric population is not well‐defined. The pharmacokinetics (PKs) of methadone is highly variable due to the variability in alpha‐1 acid glycoprotein (AAG) and genotypic...

Descripción completa

Detalles Bibliográficos
Autores principales: Aruldhas, Blessed W., Quinney, Sara K., Overholser, Brian R., Heathman, Michael A., Masters, Andrea R., Ly, Reynold C., Gao, Hongyu, Packiasabapathy, Senthil, Sadhasivam, Senthilkumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8520746/
https://www.ncbi.nlm.nih.gov/pubmed/34435753
http://dx.doi.org/10.1002/psp4.12687

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8520746/
https://www.ncbi.nlm.nih.gov/pubmed/34435753
http://dx.doi.org/10.1002/psp4.12687

Ejemplares similares