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Investigation of the Possible Allostery of Koumine Extracted From Gelsemium elegans Benth. And Analgesic Mechanism Associated With Neurosteroids

Translocator protein 18 kDa (TSPO) is an evolutionarily conserved 5-transmembrane domain protein, and has been considered as an important therapeutic target for the treatment of pain. We have recently reported the in vitro and in vivo pharmacological characterization of koumine as a TSPO positive al...

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Detalles Bibliográficos
Autores principales: Xiong, Bojun, You, Wenbing, Luo, Yufei, Jin, Guilin, Wu, Minxia, Xu, Ying, Yang, Jian, Huang, Huihui, Yu, Changxi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8520994/
https://www.ncbi.nlm.nih.gov/pubmed/34671258
http://dx.doi.org/10.3389/fphar.2021.739618