Joint Analysis of Genetic Correlation, Mendelian Randomization and Colocalization Highlights the Bi-Directional Causal Association Between Hypothyroidism and Primary Biliary Cirrhosis

Background: Hypothyroidism and primary biliary cirrhosis (PBC) are often co-existed in observational epidemiological studies. However, the causal relationship between them remains unclear. Methods: Genetic correlation, Mendelian randomization (MR) and colocalization analysis were combined to assess...

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Detalles Bibliográficos
Autores principales: Wang, Yanjun, Guo, Ping, Zhang, Yanan, Liu, Lu, Yan, Ran, Yuan, Zhongshang, Song, Yongfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8521021/
https://www.ncbi.nlm.nih.gov/pubmed/34671386
http://dx.doi.org/10.3389/fgene.2021.753352

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8521021/
https://www.ncbi.nlm.nih.gov/pubmed/34671386
http://dx.doi.org/10.3389/fgene.2021.753352

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