Isoginkgetin treatment attenuated lipopolysaccharide-induced monoamine neurotransmitter deficiency and depression-like behaviors through downregulating p38/NF-κB signaling pathway and suppressing microglia-induced apoptosis

BACKGROUND: Microglia activation-induced neuroinflammation may contribute to the etiology of depression. Podocarpus nagi containing high concentration of isoginkgetin could effectively treat mental diseases in ancient times. However, the therapeutic role, peculiarly in the brain–immune modulation in...

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Detalles Bibliográficos
Autores principales: Li, Peng, Zhang, Fucheng, Li, Yajuan, Zhang, Cai, Yang, Zhiyou, Zhang, Yongping, Song, Cai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Original Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8521360/
https://www.ncbi.nlm.nih.gov/pubmed/34281416
http://dx.doi.org/10.1177/02698811211032473

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8521360/
https://www.ncbi.nlm.nih.gov/pubmed/34281416
http://dx.doi.org/10.1177/02698811211032473

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