Antisense inhibition of the Escherichia coli NrdAB aerobic ribonucleotide reductase is bactericidal due to induction of DNA strand breaks

BACKGROUND: Antisense peptide nucleic acids (PNAs) constitute an alternative to traditional antibiotics, by their ability to silence essential genes. OBJECTIVES: To evaluate the antibacterial effects of antisense PNA-peptide conjugates that target the gene encoding the alpha subunit (NrdA) of the Es...

Descripción completa

Detalles Bibliográficos
Autores principales: Campion, Christopher, Charbon, Godefroid, Thomsen, Thomas T, Nielsen, Peter E, Løbner-Olesen, Anders
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8521395/
https://www.ncbi.nlm.nih.gov/pubmed/34450639
http://dx.doi.org/10.1093/jac/dkab305

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8521395/
https://www.ncbi.nlm.nih.gov/pubmed/34450639
http://dx.doi.org/10.1093/jac/dkab305

Ejemplares similares