Cargando…

Antisense inhibition of the Escherichia coli NrdAB aerobic ribonucleotide reductase is bactericidal due to induction of DNA strand breaks

BACKGROUND: Antisense peptide nucleic acids (PNAs) constitute an alternative to traditional antibiotics, by their ability to silence essential genes. OBJECTIVES: To evaluate the antibacterial effects of antisense PNA-peptide conjugates that target the gene encoding the alpha subunit (NrdA) of the Es...

Descripción completa

Detalles Bibliográficos
Autores principales:	Campion, Christopher, Charbon, Godefroid, Thomsen, Thomas T, Nielsen, Peter E, Løbner-Olesen, Anders
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8521395/ https://www.ncbi.nlm.nih.gov/pubmed/34450639 http://dx.doi.org/10.1093/jac/dkab305

Ejemplares similares

Bactericidal Antibiotics Increase Hydroxyphenyl Fluorescein Signal by Altering Cell Morphology
por: Paulander, Wilhelm, et al.
Publicado: (2014)

A nucleotide-sensing oligomerization mechanism that controls NrdR-dependent transcription of ribonucleotide reductases
por: Rozman Grinberg, Inna, et al.
Publicado: (2022)

The Bacillus anthracis class Ib ribonucleotide reductase subunit NrdF intrinsically selects manganese over iron
por: Grāve, Kristīne, et al.
Publicado: (2020)

Activating the Cpx response induces tolerance to antisense PNA delivered by an arginine-rich peptide in Escherichia coli
por: Frimodt-Møller, Jakob, et al.
Publicado: (2021)

NrdH-Redoxin Protein Mediates High Enzyme Activity in Manganese-reconstituted Ribonucleotide Reductase from Bacillus anthracis
por: Crona, Mikael, et al.
Publicado: (2011)

Function of the Pseudomonas aeruginosa NrdR Transcription Factor: Global Transcriptomic Analysis and Its Role on Ribonucleotide Reductase Gene Expression
por: Crespo, Anna, et al.
Publicado: (2015)

Coping with Reactive Oxygen Species to Ensure Genome Stability in Escherichia coli
por: Mendoza-Chamizo, Belén, et al.
Publicado: (2018)

Arresting chromosome replication upon energy starvation in Escherichia coli
por: Charbon, Godefroid, et al.
Publicado: (2021)

Redox-controlled reorganization and flavin strain within the ribonucleotide reductase R2b–NrdI complex monitored by serial femtosecond crystallography
por: John, Juliane, et al.
Publicado: (2022)

Multiple DNA Binding Proteins Contribute to Timing of Chromosome Replication in E. coli
por: Riber, Leise, et al.
Publicado: (2016)

Energy Starvation Induces a Cell Cycle Arrest in Escherichia coli by Triggering Degradation of the DnaA Initiator Protein
por: Charbon, Godefroid, et al.
Publicado: (2021)

Control regions for chromosome replication are conserved with respect to sequence and location among Escherichia coli strains
por: Frimodt-Møller, Jakob, et al.
Publicado: (2015)

DNA Replication Control Is Linked to Genomic Positioning of Control Regions in Escherichia coli
por: Frimodt-Møller, Jakob, et al.
Publicado: (2016)

Chromosome replication as a measure of bacterial growth rate during Escherichia coli infection in the mouse peritonitis model
por: Haugan, Maria Schei, et al.
Publicado: (2018)

Counting Replication Origins to Measure Growth of Pathogens
por: Charbon, Godefroid, et al.
Publicado: (2020)

Redox-induced structural changes in the di-iron and di-manganese forms of Bacillus anthracis ribonucleotide reductase subunit NrdF suggest a mechanism for gating of radical access
por: Grāve, Kristīne, et al.
Publicado: (2019)

Oxidative DNA damage is instrumental in hyperreplication stress-induced inviability of Escherichia coli
por: Charbon, Godefroid, et al.
Publicado: (2014)

Convergent allostery in ribonucleotide reductase
por: Thomas, William C., et al.
Publicado: (2019)

The periodic table of ribonucleotide reductases
por: Ruskoski, Terry B., et al.
Publicado: (2021)

Re-wiring of energy metabolism promotes viability during hyperreplication stress in E. coli
por: Charbon, Godefroid, et al.
Publicado: (2017)

The tyrosyl free radical in ribonucleotide reductase.
por: Gräslund, A, et al.
Publicado: (1985)

Growth Rate of Escherichia coli During Human Urinary Tract Infection: Implications for Antibiotic Effect
por: Haugan, Maria Schei, et al.
Publicado: (2019)

Rational polynomial representation of ribonucleotide reductase activity
por: Radivoyevitch, Tomas, et al.
Publicado: (2005)

Ribonucleotide reductases: essential enzymes for bacterial life
por: Torrents, Eduard
Publicado: (2014)

Structural basis for proficient oxidized ribonucleotide insertion in double strand break repair
por: Jamsen, Joonas A., et al.
Publicado: (2021)

Hydroxyurea-Mediated Cytotoxicity Without Inhibition of Ribonucleotide Reductase
por: Liew, Li Phing, et al.
Publicado: (2016)

Structural determinants and distribution of phosphate specificity in ribonucleotide reductases
por: Schell, Eugen, et al.
Publicado: (2021)

Ribonucleotide reductase, a novel drug target for gonorrhea
por: Narasimhan, Jana, et al.
Publicado: (2022)

Inhibitors of the Cancer Target Ribonucleotide Reductase, Past and Present
por: Huff, Sarah E., et al.
Publicado: (2022)

Kinetic model for reversible radical transfer in ribonucleotide reductase
por: Reinhardt, Clorice R., et al.
Publicado: (2022)

Iron chelation increases the tolerance of Escherichia coli to hyper-replication stress
por: Charbon, Godefroid, et al.
Publicado: (2018)

A rapid and sensitive assay for quantifying the activity of both aerobic and anaerobic ribonucleotide reductases acting upon any or all substrates
por: Levitz, Talya S., et al.
Publicado: (2022)

Subcellular Protein Localization by Using a Genetically Encoded Fluorescent Amino Acid
por: Charbon, Godefroid, et al.
Publicado: (2011)

Regulation of ribonucleotide reductase M2 expression by the upstream AUGs
por: Dong, Zizheng, et al.
Publicado: (2005)

A docking model of human ribonucleotide reductase with flavin and phenosafranine
por: Priya, Panneerselvam Lakshmi, et al.
Publicado: (2009)

Biofilm Modifies Expression of Ribonucleotide Reductase Genes in Escherichia coli
por: Cendra, Maria del Mar, et al.
Publicado: (2012)

Ribonucleotide reductase is not limiting for mitochondrial DNA copy number in mice
por: Ylikallio, Emil, et al.
Publicado: (2010)

Targeting the Large Subunit of Human Ribonucleotide Reductase for Cancer Chemotherapy
por: Wijerathna, Sanath R., et al.
Publicado: (2011)

The Efficacy of the Ribonucleotide Reductase Inhibitor Didox in Preclinical Models of AML
por: Cook, Guerry J., et al.
Publicado: (2014)

Structure-guided design of anti-cancer ribonucleotide reductase inhibitors
por: Misko, Tessianna A., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_2m04le3au0kmjdje40ckilv216