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p38 MAPK‐mediated loss of nuclear RNase III enzyme Drosha underlies amyloid beta‐induced neuronal stress in Alzheimer's disease

MicroRNAs (miRNAs) are small noncoding RNAs ubiquitously expressed in the brain and regulate gene expression at the post‐transcriptional level. The nuclear RNase III enzyme Drosha initiates the maturation process of miRNAs in the nucleus. Strong evidence suggests that dysregulation of miRNAs is invo...

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Detalles Bibliográficos
Autores principales: Xu, Haidong, Liu, Xiaolei, Li, Wenming, Xi, Ye, Su, Peng, Meng, Bo, Shao, Xiaoyun, Tang, Beisha, Yang, Qian, Mao, Zixu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8521488/
https://www.ncbi.nlm.nih.gov/pubmed/34528746
http://dx.doi.org/10.1111/acel.13434