Exploitation of E. coli for the production of penicillin G amidase: a tool for the synthesis of semisynthetic β-lactam antibiotics

BACKGROUND: Penicillin G amidase/acylases from microbial sources is a unique enzyme that belongs to the N-terminal nucleophilic hydrolase structural superfamily. It catalyzes the selective hydrolysis of side chain amide/acyl bond of penicillins and cephalosporins whereas the labile amide/acyl bond i...

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Detalles Bibliográficos
Autores principales: Sambyal, Krishika, Singh, Rahul Vikram
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8521562/
https://www.ncbi.nlm.nih.gov/pubmed/34652570
http://dx.doi.org/10.1186/s43141-021-00263-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8521562/
https://www.ncbi.nlm.nih.gov/pubmed/34652570
http://dx.doi.org/10.1186/s43141-021-00263-7

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