BRCA1/Trp53 heterozygosity and replication stress drive esophageal cancer development in a mouse model

BRCA1 germline mutations are associated with an increased risk of breast and ovarian cancer. Recent findings of others suggest that BRCA1 mutation carriers also bear an increased risk of esophageal and gastric cancer. Here, we employ a Brca1/Trp53 mouse model to show that unresolved replication stre...

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Detalles Bibliográficos
Autores principales: He, Ye, Rivera, Joshua, Diossy, Miklos, Duan, Haohui, Bowman-Colin, Christian, Reed, Rachel, Jennings, Rebecca, Novak, Jesse, Tran, Stevenson V., Cohen, Elizabeth F., Szuts, David, Giobbie-Hurder, Anita, Bronson, Roderick T., Bass, Adam J., Signoretti, Sabina, Szallasi, Zoltan, Livingston, David M., Pathania, Shailja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8521688/
https://www.ncbi.nlm.nih.gov/pubmed/34607954
http://dx.doi.org/10.1073/pnas.2108421118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8521688/
https://www.ncbi.nlm.nih.gov/pubmed/34607954
http://dx.doi.org/10.1073/pnas.2108421118

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