Optimizing Aggregated N-Of-1 Trial Designs for Predictive Biomarker Validation: Statistical Methods and Theoretical Findings

Background and Significance: Parallel-group randomized controlled trials (PG-RCTs) are the gold standard for detecting differences in mean improvement across treatment conditions. However, PG-RCTs provide limited information about individuals, making them poorly optimized for quantifying the relatio...

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Detalles Bibliográficos
Autores principales: Hendrickson, Rebecca C., Thomas, Ronald G., Schork, Nicholas J., Raskind, Murray A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Digital Health
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8521797/
https://www.ncbi.nlm.nih.gov/pubmed/34713026
http://dx.doi.org/10.3389/fdgth.2020.00013

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8521797/
https://www.ncbi.nlm.nih.gov/pubmed/34713026
http://dx.doi.org/10.3389/fdgth.2020.00013

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