Impaired antioxidant KEAP1-NRF2 system in amyotrophic lateral sclerosis: NRF2 activation as a potential therapeutic strategy

BACKGROUND: Oxidative stress (OS) is an imbalance between oxidant and antioxidant species and, together with other numerous pathological mechanisms, leads to the degeneration and death of motor neurons (MNs) in amyotrophic lateral sclerosis (ALS). MAIN BODY: Two of the main players in the molecular...

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Detalles Bibliográficos
Autores principales: Bono, Silvia, Feligioni, Marco, Corbo, Massimo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8521937/
https://www.ncbi.nlm.nih.gov/pubmed/34663413
http://dx.doi.org/10.1186/s13024-021-00479-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8521937/
https://www.ncbi.nlm.nih.gov/pubmed/34663413
http://dx.doi.org/10.1186/s13024-021-00479-8

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