Inefficient quality control of ribosome stalling during APP synthesis generates CAT-tailed species that precipitate hallmarks of Alzheimer’s disease

Amyloid precursor protein (APP) metabolism is central to Alzheimer’s disease (AD) pathogenesis, but the key etiological driver remains elusive. Recent failures of clinical trials targeting amyloid-β (Aβ) peptides, the proteolytic fragments of amyloid precursor protein (APP) that are the main compone...

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Detalles Bibliográficos
Autores principales: Rimal, Suman, Li, Yu, Vartak, Rasika, Geng, Ji, Tantray, Ishaq, Li, Shuangxi, Huh, Sungun, Vogel, Hannes, Glabe, Charles, Grinberg, Lea T., Spina, Salvatore, Seeley, William W., Guo, Su, Lu, Bingwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8522249/
https://www.ncbi.nlm.nih.gov/pubmed/34663454
http://dx.doi.org/10.1186/s40478-021-01268-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8522249/
https://www.ncbi.nlm.nih.gov/pubmed/34663454
http://dx.doi.org/10.1186/s40478-021-01268-6

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