Pregnancy outcome in thoracic aortic disease data from the Registry Of Pregnancy And Cardiac disease
BACKGROUND: Cardiovascular disease is the leading cause of death during pregnancy with thoracic aortic dissection being one of the main causes. Thoracic aortic disease is commonly related to hereditary disorders and congenital heart malformations such as bicuspid aortic valve (BAV). Pregnancy is con...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8522458/ https://www.ncbi.nlm.nih.gov/pubmed/33468574 http://dx.doi.org/10.1136/heartjnl-2020-318183 |
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author | Campens, Laurence Baris, Lucia Scott, Nandita S. Broberg, Craig S Bondue, Antione Jondeau, Guillaume Grewal, Jasmine Johnson, Mark R Hall, Roger De Backer, Julie Roos-Hesselink, Jolien W |
author_facet | Campens, Laurence Baris, Lucia Scott, Nandita S. Broberg, Craig S Bondue, Antione Jondeau, Guillaume Grewal, Jasmine Johnson, Mark R Hall, Roger De Backer, Julie Roos-Hesselink, Jolien W |
author_sort | Campens, Laurence |
collection | PubMed |
description | BACKGROUND: Cardiovascular disease is the leading cause of death during pregnancy with thoracic aortic dissection being one of the main causes. Thoracic aortic disease is commonly related to hereditary disorders and congenital heart malformations such as bicuspid aortic valve (BAV). Pregnancy is considered a high risk period in women with underlying aortopathy. METHODS: The ESC EORP Registry Of Pregnancy And Cardiac disease (ROPAC) is a prospective global registry that enrolled 5739 women with pre-existing cardiac disease. With this analysis, we aim to study the maternal and fetal outcome of pregnancy in women with thoracic aortic disease. RESULTS: Thoracic aortic disease was reported in 189 women (3.3%). Half of them were patients with Marfan syndrome (MFS), 26% had a BAV, 8% Turner syndrome, 2% vascular Ehlers-Danlos syndrome and 11% had no underlying genetic defect or associated congenital heart defect. Aortic dilatation was reported in 58% of patients and 6% had a history of aortic dissection. Four patients, of whom three were patients with MFS, had an acute aortic dissection (three type A and one type B aortic dissection) without maternal or fetal mortality. No complications occurred in women with a history of aortic dissection. There was no significant difference in median fetal birth weight if treated with a beta-blocker or not (2960 g (2358–3390 g) vs 3270 g (2750–3570 g), p value 0.25). CONCLUSION: This ancillary analysis provides the largest prospective data review on pregnancy risk for patients with thoracic aortic disease. Overall pregnancy outcomes in women with thoracic aortic disease followed according to current guidelines are good. |
format | Online Article Text |
id | pubmed-8522458 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-85224582021-10-29 Pregnancy outcome in thoracic aortic disease data from the Registry Of Pregnancy And Cardiac disease Campens, Laurence Baris, Lucia Scott, Nandita S. Broberg, Craig S Bondue, Antione Jondeau, Guillaume Grewal, Jasmine Johnson, Mark R Hall, Roger De Backer, Julie Roos-Hesselink, Jolien W Heart Aortic and Vascular Disease BACKGROUND: Cardiovascular disease is the leading cause of death during pregnancy with thoracic aortic dissection being one of the main causes. Thoracic aortic disease is commonly related to hereditary disorders and congenital heart malformations such as bicuspid aortic valve (BAV). Pregnancy is considered a high risk period in women with underlying aortopathy. METHODS: The ESC EORP Registry Of Pregnancy And Cardiac disease (ROPAC) is a prospective global registry that enrolled 5739 women with pre-existing cardiac disease. With this analysis, we aim to study the maternal and fetal outcome of pregnancy in women with thoracic aortic disease. RESULTS: Thoracic aortic disease was reported in 189 women (3.3%). Half of them were patients with Marfan syndrome (MFS), 26% had a BAV, 8% Turner syndrome, 2% vascular Ehlers-Danlos syndrome and 11% had no underlying genetic defect or associated congenital heart defect. Aortic dilatation was reported in 58% of patients and 6% had a history of aortic dissection. Four patients, of whom three were patients with MFS, had an acute aortic dissection (three type A and one type B aortic dissection) without maternal or fetal mortality. No complications occurred in women with a history of aortic dissection. There was no significant difference in median fetal birth weight if treated with a beta-blocker or not (2960 g (2358–3390 g) vs 3270 g (2750–3570 g), p value 0.25). CONCLUSION: This ancillary analysis provides the largest prospective data review on pregnancy risk for patients with thoracic aortic disease. Overall pregnancy outcomes in women with thoracic aortic disease followed according to current guidelines are good. BMJ Publishing Group 2021-11 2021-01-19 /pmc/articles/PMC8522458/ /pubmed/33468574 http://dx.doi.org/10.1136/heartjnl-2020-318183 Text en © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) . |
spellingShingle | Aortic and Vascular Disease Campens, Laurence Baris, Lucia Scott, Nandita S. Broberg, Craig S Bondue, Antione Jondeau, Guillaume Grewal, Jasmine Johnson, Mark R Hall, Roger De Backer, Julie Roos-Hesselink, Jolien W Pregnancy outcome in thoracic aortic disease data from the Registry Of Pregnancy And Cardiac disease |
title | Pregnancy outcome in thoracic aortic disease data from the Registry Of Pregnancy And Cardiac disease |
title_full | Pregnancy outcome in thoracic aortic disease data from the Registry Of Pregnancy And Cardiac disease |
title_fullStr | Pregnancy outcome in thoracic aortic disease data from the Registry Of Pregnancy And Cardiac disease |
title_full_unstemmed | Pregnancy outcome in thoracic aortic disease data from the Registry Of Pregnancy And Cardiac disease |
title_short | Pregnancy outcome in thoracic aortic disease data from the Registry Of Pregnancy And Cardiac disease |
title_sort | pregnancy outcome in thoracic aortic disease data from the registry of pregnancy and cardiac disease |
topic | Aortic and Vascular Disease |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8522458/ https://www.ncbi.nlm.nih.gov/pubmed/33468574 http://dx.doi.org/10.1136/heartjnl-2020-318183 |
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