Pregnancy outcome in thoracic aortic disease data from the Registry Of Pregnancy And Cardiac disease

BACKGROUND: Cardiovascular disease is the leading cause of death during pregnancy with thoracic aortic dissection being one of the main causes. Thoracic aortic disease is commonly related to hereditary disorders and congenital heart malformations such as bicuspid aortic valve (BAV). Pregnancy is con...

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Autores principales: Campens, Laurence, Baris, Lucia, Scott, Nandita S., Broberg, Craig S, Bondue, Antione, Jondeau, Guillaume, Grewal, Jasmine, Johnson, Mark R, Hall, Roger, De Backer, Julie, Roos-Hesselink, Jolien W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8522458/
https://www.ncbi.nlm.nih.gov/pubmed/33468574
http://dx.doi.org/10.1136/heartjnl-2020-318183
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author Campens, Laurence
Baris, Lucia
Scott, Nandita S.
Broberg, Craig S
Bondue, Antione
Jondeau, Guillaume
Grewal, Jasmine
Johnson, Mark R
Hall, Roger
De Backer, Julie
Roos-Hesselink, Jolien W
author_facet Campens, Laurence
Baris, Lucia
Scott, Nandita S.
Broberg, Craig S
Bondue, Antione
Jondeau, Guillaume
Grewal, Jasmine
Johnson, Mark R
Hall, Roger
De Backer, Julie
Roos-Hesselink, Jolien W
author_sort Campens, Laurence
collection PubMed
description BACKGROUND: Cardiovascular disease is the leading cause of death during pregnancy with thoracic aortic dissection being one of the main causes. Thoracic aortic disease is commonly related to hereditary disorders and congenital heart malformations such as bicuspid aortic valve (BAV). Pregnancy is considered a high risk period in women with underlying aortopathy. METHODS: The ESC EORP Registry Of Pregnancy And Cardiac disease (ROPAC) is a prospective global registry that enrolled 5739 women with pre-existing cardiac disease. With this analysis, we aim to study the maternal and fetal outcome of pregnancy in women with thoracic aortic disease. RESULTS: Thoracic aortic disease was reported in 189 women (3.3%). Half of them were patients with Marfan syndrome (MFS), 26% had a BAV, 8% Turner syndrome, 2% vascular Ehlers-Danlos syndrome and 11% had no underlying genetic defect or associated congenital heart defect. Aortic dilatation was reported in 58% of patients and 6% had a history of aortic dissection. Four patients, of whom three were patients with MFS, had an acute aortic dissection (three type A and one type B aortic dissection) without maternal or fetal mortality. No complications occurred in women with a history of aortic dissection. There was no significant difference in median fetal birth weight if treated with a beta-blocker or not (2960 g (2358–3390 g) vs 3270 g (2750–3570 g), p value 0.25). CONCLUSION: This ancillary analysis provides the largest prospective data review on pregnancy risk for patients with thoracic aortic disease. Overall pregnancy outcomes in women with thoracic aortic disease followed according to current guidelines are good.
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spelling pubmed-85224582021-10-29 Pregnancy outcome in thoracic aortic disease data from the Registry Of Pregnancy And Cardiac disease Campens, Laurence Baris, Lucia Scott, Nandita S. Broberg, Craig S Bondue, Antione Jondeau, Guillaume Grewal, Jasmine Johnson, Mark R Hall, Roger De Backer, Julie Roos-Hesselink, Jolien W Heart Aortic and Vascular Disease BACKGROUND: Cardiovascular disease is the leading cause of death during pregnancy with thoracic aortic dissection being one of the main causes. Thoracic aortic disease is commonly related to hereditary disorders and congenital heart malformations such as bicuspid aortic valve (BAV). Pregnancy is considered a high risk period in women with underlying aortopathy. METHODS: The ESC EORP Registry Of Pregnancy And Cardiac disease (ROPAC) is a prospective global registry that enrolled 5739 women with pre-existing cardiac disease. With this analysis, we aim to study the maternal and fetal outcome of pregnancy in women with thoracic aortic disease. RESULTS: Thoracic aortic disease was reported in 189 women (3.3%). Half of them were patients with Marfan syndrome (MFS), 26% had a BAV, 8% Turner syndrome, 2% vascular Ehlers-Danlos syndrome and 11% had no underlying genetic defect or associated congenital heart defect. Aortic dilatation was reported in 58% of patients and 6% had a history of aortic dissection. Four patients, of whom three were patients with MFS, had an acute aortic dissection (three type A and one type B aortic dissection) without maternal or fetal mortality. No complications occurred in women with a history of aortic dissection. There was no significant difference in median fetal birth weight if treated with a beta-blocker or not (2960 g (2358–3390 g) vs 3270 g (2750–3570 g), p value 0.25). CONCLUSION: This ancillary analysis provides the largest prospective data review on pregnancy risk for patients with thoracic aortic disease. Overall pregnancy outcomes in women with thoracic aortic disease followed according to current guidelines are good. BMJ Publishing Group 2021-11 2021-01-19 /pmc/articles/PMC8522458/ /pubmed/33468574 http://dx.doi.org/10.1136/heartjnl-2020-318183 Text en © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Aortic and Vascular Disease
Campens, Laurence
Baris, Lucia
Scott, Nandita S.
Broberg, Craig S
Bondue, Antione
Jondeau, Guillaume
Grewal, Jasmine
Johnson, Mark R
Hall, Roger
De Backer, Julie
Roos-Hesselink, Jolien W
Pregnancy outcome in thoracic aortic disease data from the Registry Of Pregnancy And Cardiac disease
title Pregnancy outcome in thoracic aortic disease data from the Registry Of Pregnancy And Cardiac disease
title_full Pregnancy outcome in thoracic aortic disease data from the Registry Of Pregnancy And Cardiac disease
title_fullStr Pregnancy outcome in thoracic aortic disease data from the Registry Of Pregnancy And Cardiac disease
title_full_unstemmed Pregnancy outcome in thoracic aortic disease data from the Registry Of Pregnancy And Cardiac disease
title_short Pregnancy outcome in thoracic aortic disease data from the Registry Of Pregnancy And Cardiac disease
title_sort pregnancy outcome in thoracic aortic disease data from the registry of pregnancy and cardiac disease
topic Aortic and Vascular Disease
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8522458/
https://www.ncbi.nlm.nih.gov/pubmed/33468574
http://dx.doi.org/10.1136/heartjnl-2020-318183
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