Coordinated pyruvate kinase activity is crucial for metabolic adaptation and cell survival during mitochondrial dysfunction

Deoxyguanosine kinase (DGUOK) deficiency causes mtDNA depletion and mitochondrial dysfunction. We reported long survival of DGUOK knockout (Dguok(−/−)) mice despite low (<5%) mtDNA content in liver tissue. However, the molecular mechanisms enabling the extended survival remain unknown. Using tran...

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Detalles Bibliográficos
Autores principales: Zhou, Xiaoshan, Mikaeloff, Flora, Curbo, Sophie, Zhao, Qian, Kuiper, Raoul, Végvári, Ákos, Neogi, Ujjwal, Karlsson, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
General Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8522632/
https://www.ncbi.nlm.nih.gov/pubmed/34169315
http://dx.doi.org/10.1093/hmg/ddab168

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8522632/
https://www.ncbi.nlm.nih.gov/pubmed/34169315
http://dx.doi.org/10.1093/hmg/ddab168

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