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Coordinated pyruvate kinase activity is crucial for metabolic adaptation and cell survival during mitochondrial dysfunction
Deoxyguanosine kinase (DGUOK) deficiency causes mtDNA depletion and mitochondrial dysfunction. We reported long survival of DGUOK knockout (Dguok(−/−)) mice despite low (<5%) mtDNA content in liver tissue. However, the molecular mechanisms enabling the extended survival remain unknown. Using tran...
Autores principales: | Zhou, Xiaoshan, Mikaeloff, Flora, Curbo, Sophie, Zhao, Qian, Kuiper, Raoul, Végvári, Ákos, Neogi, Ujjwal, Karlsson, Anna |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8522632/ https://www.ncbi.nlm.nih.gov/pubmed/34169315 http://dx.doi.org/10.1093/hmg/ddab168 |
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