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Mapping of pseudouridine residues on cellular and viral transcripts using a novel antibody-based technique

Pseudouridine (Ψ) is the most common noncanonical ribonucleoside present on mammalian noncoding RNAs (ncRNAs), including rRNAs, tRNAs, and snRNAs, where it contributes ∼7% of the total uridine level. However, Ψ constitutes only ∼0.1% of the uridines present on mRNAs and its effect on mRNA function r...

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Detalles Bibliográficos
Autores principales: Martinez Campos, Cecilia, Tsai, Kevin, Courtney, David G., Bogerd, Hal P., Holley, Christopher L., Cullen, Bryan R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8522693/
https://www.ncbi.nlm.nih.gov/pubmed/34376564
http://dx.doi.org/10.1261/rna.078940.121