SARS-CoV-2 infection triggers widespread host mRNA decay leading to an mRNA export block

The transcriptional induction of interferon (IFN) genes is a key feature of the mammalian antiviral response that limits viral replication and dissemination. A hallmark of severe COVID-19 disease caused by SARS-CoV-2 is the low presence of IFN proteins in patient serum despite elevated levels of IFN...

Descripción completa

Detalles Bibliográficos
Autores principales: Burke, James M., St Clair, Laura A., Perera, Rushika, Parker, Roy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8522697/
https://www.ncbi.nlm.nih.gov/pubmed/34315815
http://dx.doi.org/10.1261/rna.078923.121

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8522697/
https://www.ncbi.nlm.nih.gov/pubmed/34315815
http://dx.doi.org/10.1261/rna.078923.121

Ejemplares similares