Structure of mycobacterial CIII(2)CIV(2) respiratory supercomplex bound to the tuberculosis drug candidate telacebec (Q203)

The imidazopyridine telacebec, also known as Q203, is one of only a few new classes of compounds in more than 50 years with demonstrated antituberculosis activity in humans. Telacebec inhibits the mycobacterial respiratory supercomplex composed of complexes III and IV (CIII(2)CIV(2)). In mycobacteri...

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Detalles Bibliográficos
Autores principales: Yanofsky, David J, Di Trani, Justin M, Król, Sylwia, Abdelaziz, Rana, Bueler, Stephanie A, Imming, Peter, Brzezinski, Peter, Rubinstein, John L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Structural Biology and Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8523172/
https://www.ncbi.nlm.nih.gov/pubmed/34590581
http://dx.doi.org/10.7554/eLife.71959

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8523172/
https://www.ncbi.nlm.nih.gov/pubmed/34590581
http://dx.doi.org/10.7554/eLife.71959

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