Combining an optimized mRNA template with a double purification process allows strong expression of in vitro transcribed mRNA

mRNA is a blooming technology for vaccination and has gained global attention during the SARS-CoV-2 pandemic. However, the recent clinical trials have highlighted increased reactogenicity when using high mRNA doses. Intending to increase the potency of mRNA therapeutics and to decrease the therapeut...

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Detalles Bibliográficos
Autores principales: Linares-Fernández, Sergio, Moreno, Julien, Lambert, Elise, Mercier-Gouy, Perrine, Vachez, Laetitia, Verrier, Bernard, Exposito, Jean-Yves
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8523304/
https://www.ncbi.nlm.nih.gov/pubmed/34692232
http://dx.doi.org/10.1016/j.omtn.2021.10.007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8523304/
https://www.ncbi.nlm.nih.gov/pubmed/34692232
http://dx.doi.org/10.1016/j.omtn.2021.10.007

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