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Combining an optimized mRNA template with a double purification process allows strong expression of in vitro transcribed mRNA
mRNA is a blooming technology for vaccination and has gained global attention during the SARS-CoV-2 pandemic. However, the recent clinical trials have highlighted increased reactogenicity when using high mRNA doses. Intending to increase the potency of mRNA therapeutics and to decrease the therapeut...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society of Gene & Cell Therapy
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8523304/ https://www.ncbi.nlm.nih.gov/pubmed/34692232 http://dx.doi.org/10.1016/j.omtn.2021.10.007 |