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Downregulation of kainate receptors regulating GABAergic transmission in amygdala after early life stress is associated with anxiety-like behavior in rodents

Early life stress (ELS) is a well-characterized risk factor for mood and anxiety disorders. GABAergic microcircuits in the amygdala are critically implicated in anxiety; however, whether their function is altered after ELS is not known. Here we identify a novel mechanism by which kainate receptors (...

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Detalles Bibliográficos
Autores principales: Englund, Jonas, Haikonen, Joni, Shteinikov, Vasilii, Amarilla, Shyrley Paola, Atanasova, Tsvetomira, Shintyapina, Alexandra, Ryazantseva, Maria, Partanen, Juha, Voikar, Vootele, Lauri, Sari E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8523542/
https://www.ncbi.nlm.nih.gov/pubmed/34663781
http://dx.doi.org/10.1038/s41398-021-01654-7