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Self-reactivity controls functional diversity of naive CD8(+) T cells by co-opting tonic type I interferon
The strength of the T cell receptor interaction with self-ligands affects antigen-specific immune responses. However, the precise function and underlying mechanisms are unclear. Here, we demonstrate that naive CD8(+) T cells with relatively high self-reactivity are phenotypically heterogeneous owing...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8523551/ https://www.ncbi.nlm.nih.gov/pubmed/34663827 http://dx.doi.org/10.1038/s41467-021-26351-3 |