Palmitoylation targets the calcineurin phosphatase to the phosphatidylinositol 4-kinase complex at the plasma membrane

Calcineurin, the conserved protein phosphatase and target of immunosuppressants, is a critical mediator of Ca(2+) signaling. Here, to discover calcineurin-regulated processes we examined an understudied isoform, CNAβ1. We show that unlike canonical cytosolic calcineurin, CNAβ1 localizes to the plasm...

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Detalles Bibliográficos
Autores principales: Ulengin-Talkish, Idil, Parson, Matthew A. H., Jenkins, Meredith L., Roy, Jagoree, Shih, Alexis Z. L., St-Denis, Nicole, Gulyas, Gergo, Balla, Tamas, Gingras, Anne-Claude, Várnai, Péter, Conibear, Elizabeth, Burke, John E., Cyert, Martha S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8523714/
https://www.ncbi.nlm.nih.gov/pubmed/34663815
http://dx.doi.org/10.1038/s41467-021-26326-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8523714/
https://www.ncbi.nlm.nih.gov/pubmed/34663815
http://dx.doi.org/10.1038/s41467-021-26326-4

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