TET2 mutations are associated with hypermethylation at key regulatory enhancers in normal and malignant hematopoiesis

Mutations in the epigenetic modifier TET2 are frequent in myeloid malignancies and clonal hematopoiesis of indeterminate potential (CHIP) and clonal cytopenia of undetermined significance (CCUS). Here, we investigate associations between TET2 mutations and DNA methylation in whole blood in 305 elder...

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Detalles Bibliográficos
Autores principales: Tulstrup, Morten, Soerensen, Mette, Hansen, Jakob Werner, Gillberg, Linn, Needhamsen, Maria, Kaastrup, Katja, Helin, Kristian, Christensen, Kaare, Weischenfeldt, Joachim, Grønbæk, Kirsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8523747/
https://www.ncbi.nlm.nih.gov/pubmed/34663818
http://dx.doi.org/10.1038/s41467-021-26093-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8523747/
https://www.ncbi.nlm.nih.gov/pubmed/34663818
http://dx.doi.org/10.1038/s41467-021-26093-2

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