Upregulation of Phosphodiesterase 2A Augments T Cell Activation by Changing cGMP/cAMP Cross-Talk

3′,5′-cyclic adenosine monophosphate (cAMP) is well-known for its diverse immunomodulatory properties, primarily inhibitory effects during T cell activation, proliferation, and production of pro-inflammatory cytokines. A decrease in cAMP levels, due to the hydrolyzing activity of phosphodiesterases...

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Detalles Bibliográficos
Autores principales: Kurelic, Roberta, Krieg, Paula F., Sonner, Jana K., Bhaiyan, Gloria, Ramos, Gustavo C., Frantz, Stefan, Friese, Manuel A., Nikolaev, Viacheslav O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8523859/
https://www.ncbi.nlm.nih.gov/pubmed/34675812
http://dx.doi.org/10.3389/fphar.2021.748798

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8523859/
https://www.ncbi.nlm.nih.gov/pubmed/34675812
http://dx.doi.org/10.3389/fphar.2021.748798

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