Pharmacological Inhibition of Inositol-Requiring Enzyme 1α RNase Activity Protects Pancreatic Beta Cell and Improves Diabetic Condition in Insulin Mutation-Induced Diabetes

β-cell ER stress plays an important role in β-cell dysfunction and death during the pathogenesis of diabetes. Proinsulin misfolding is regarded as one of the primary initiating factors of ER stress and unfolded protein response (UPR) activation in β-cells. Here, we found that the ER stress sensor in...

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Detalles Bibliográficos
Autores principales: Herlea-Pana, Oana, Eeda, Venkateswararao, Undi, Ram Babu, Lim, Hui-Ying, Wang, Weidong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8524045/
https://www.ncbi.nlm.nih.gov/pubmed/34675883
http://dx.doi.org/10.3389/fendo.2021.749879

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8524045/
https://www.ncbi.nlm.nih.gov/pubmed/34675883
http://dx.doi.org/10.3389/fendo.2021.749879

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