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The combined effect of permeation enhancement and proteolysis inhibition on the systemic exposure of orally administrated peptides: Salcaprozate sodium, soybean trypsin inhibitor, and teriparatide study in pigs

Oral delivery of peptides and proteins is hindered by their rapid proteolysis in the gastrointestinal tract and their inability to permeate biological membranes. Various drug delivery approaches are being investigated and implemented to overcome these obstacles. In the discussed study conducted in p...

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Detalles Bibliográficos
Autores principales: Burshtein, Gregory, Itin, Constantin, Tang, Jonathan C.Y., Galitzer, Hillel, Fraser, William D., Schwartz, Phillip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8524144/
https://www.ncbi.nlm.nih.gov/pubmed/34704013
http://dx.doi.org/10.1016/j.ijpx.2021.100097