In vitro investigations into the roles of CYP450 enzymes and drug transporters in the drug interactions of zanubrutinib, a covalent Bruton's tyrosine kinase inhibitor

Zanubrutinib is a highly selective, potent, orally available, targeted covalent inhibitor (TCI) of Bruton's tyrosine kinase (BTK). This work investigated the in vitro drug metabolism and transport of zanubrutinib, and its potential for clinical drug–drug interactions (DDIs). Phenotyping studies...

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Detalles Bibliográficos
Autores principales: Zhang, Heather, Ou, Ying C., Su, Dan, Wang, Fan, Wang, Lai, Sahasranaman, Srikumar, Tang, Zhiyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8524670/
https://www.ncbi.nlm.nih.gov/pubmed/34664792
http://dx.doi.org/10.1002/prp2.870

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8524670/
https://www.ncbi.nlm.nih.gov/pubmed/34664792
http://dx.doi.org/10.1002/prp2.870

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