Targeting PPARα in low ambient temperature exposure-induced cardiac dysfunction and remodeling

The present study demonstrates that the down-regulation of peroxisome proliferator-activated receptor-α (PPARα) results in chronic low ambient temperature (LT) exposure-induced cardiac dysfunction and remodeling, emphasizing the therapeutic potential of PPARα activation strategies (e.g. fenofibrate...

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Detalles Bibliográficos
Autores principales: Chen, Xi-Yao, Jiao, Yang, Zhang, Fu-Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8524846/
https://www.ncbi.nlm.nih.gov/pubmed/34663467
http://dx.doi.org/10.1186/s40779-021-00347-y
Descripción
Sumario:The present study demonstrates that the down-regulation of peroxisome proliferator-activated receptor-α (PPARα) results in chronic low ambient temperature (LT) exposure-induced cardiac dysfunction and remodeling, emphasizing the therapeutic potential of PPARα activation strategies (e.g. fenofibrate treatment) in LT-associated cardiac injury. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s40779-021-00347-y.

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